Aim: Down syndrome is the most common chromosomal abnormality, which is associated with many coexisting health conditions, which result in their immune dysfunction. The coronavirus pandemic (COVID-19) has affected the lives of all people in the two years of its spread, as it is characterized by the rapid development of acute respiratory distress syndrome and other serious complications in people with the disease. According to Espinosa (2020), people with Down syndrome belong to high-risk groups, thus isolating and limiting them from their usual occupations. The consequent restraint measures (quarantineisolation) applied in Greece had an impact on people's mental health. The present study studies the quality of life of people with Down syndrome compared to their parents / guardians during the coronavirus pandemic.

Method - Sample: The research was conducted with specific ion criteria, in which 12 adults with Down syndrome and their 12 parents / guardians participated, with the evaluation tool of the Health questionnaire, SF-36.

Outcomes: Conclusions: Emotional status, general health status and pain affected parents / guardians more strongly than people with Down syndrome. However, a significant difference arises in the awareness of their health status, where people with Down Syndrome have a better perception of their health than their parents / guardians.